novel technology in continuous flow chemistry
FLOW TECHNOLOGY
- Automated synthesis of 5 molecules at one time
- Compact setup (a fume hood size)
- Only one offline purification
- Reduced time and cost
SPS-Flow Synthesis
SPS-Flow Casestudy
“A six-step prexasertib synthesis was achieved in a remarkable 65% overall isolated yield with a final purity of >99.9%. In addition, 23 prexasertib analogues were synthesized... These analogues display both early and late-stage diversification, showcasing the ability to readily alter any portion of a molecule to explore structure–activity relationships.”
Mark S. Kerr & Kevin P. Cole
Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, IN, USA.
Our in-house reactor design for continuous flow coupled with photochemical module has enable novel transformation up to Kilogram/day of production
SPS-Flow Synthesizer
Kg-scale flow synthesis
SPS-Flow Synthesizer
- Automated synthesis of 5 molecules at one time
- Compact setup (a fume hood size)
- Only one offline purification
- Reduced time and cost
SPS-Flow Synthesis
SPS-Flow Casestudy
“A six-step prexasertib synthesis was achieved in a remarkable 65% overall isolated yield with a final purity of >99.9%. In addition, 23 prexasertib analogues were synthesized… These analogues display both early and late-stage diversification, showcasing the ability to readily alter any portion of a molecule to explore structure–activity relationships.”Mark S. Kerr & Kevin P. Cole
Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, IN, USA. SPS-Flow Synthesis of Prexasertib
Review
Kg-scale flow synthesis
Our in-house reactor design for continuous flow coupled with photochemical module has enable novel transformation up to Kilogram/day of production
